Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 30UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population
نویسندگان
چکیده
Edhyana Sahiratmadja, Frank T. Wieringa, Reinout van Crevel, Adriëtte W. de Visser, Iskandar Adnan, Bachti Alisjahbana, Eline Slagboom, Sangkot Marzuki, Tom H. M. Ottenhoff, Esther van de Vosse and Joannes J. M. Marx* Eijkman Institute for Molecular Biology, Jakarta, Indonesia Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Leiden, The Netherlands Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands Department of Internal Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands Division of Tropical and Infection Diseases, Department of Internal Medicine, Medicine Faculty of University of Padjadjaran, Bandung, Indonesia Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Eijkman Winkler Institute for Microbiology, Infectious Diseases and Inflammation, University Medical Centre Utrecht, postnr. G04.614, PO Box 85500, 3508, GA Utrecht, The Netherlands
منابع مشابه
Iron deficiency and NRAMP1 polymorphisms (INT4, D543N and 3'UTR) do not contribute to severity of anaemia in tuberculosis in the Indonesian population.
Fe-deficiency anaemia is the most common cause of anaemia in developing countries. In these settings, many chronic infections, including tuberculosis (TB), are highly prevalent. Fe is an essential nutrient for both host and mycobacteria that play a pivotal role in host immunity and mycobacterial growth. A case-control study was performed in a TB-endemic region in Jakarta, Indonesia, among 378 p...
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BACKGROUND Ample evidence suggests that host genetic factors affect human susceptibility to tuberculosis. The natural resistance-associated macrophage protein 1 (NRAMP1) gene seems to play a role in the pathophysiology of a number of intracellular infections, including mycobacteria. A case-control study was conducted in the Greek population to determine whether NRAMP1 polymorphisms affect the s...
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BACKGROUND Natural resistance associated macrophage protein 1 (NRAMP1), encoded by the SLC11A1 gene, has been described to regulate macrophage activation and be associated with infectious and autoimmune diseases. The relation between SLC11A1 polymorphisms and tuberculosis susceptibility has been studied in different populations. METHODS We systematically reviewed published studies on SLC11A1 ...
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The aim of this study was to evaluate the role of three polymorphisms (D543N, TGTG deletion in 3' UTR, INT4 G/C) of NRAMP1 to susceptibility to lung tuberculosis (TB) disease. The results showed that homozygous TGTG deletion in 3'UTR of NRAMP1 was found more frequent in lung tuberculosis patients than in healthy nurses working in a TB ward. This 4 base deletion might cause malfunction of NRAMP1...
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BACKGROUND Rheumatoid arthritis is a chronic inflammatory disease whose cause has not been fully elucidated. However, genetic factors seem to have an important role in its pathogenesis. OBJECTIVE We analyzed the possible association between rheumatoid arthritis and variants of the SLC11A1 gene, which encodes for NRAMP1, a protein involved in the activation of phagocytes and synthesis of proin...
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